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Ingredient-Specific Particle Sizing of Aerosolized Nasal Spray Using Wide-Field Raman Chemical Imaging
17 Mar 2009: Creating the correct nasal formulation for intranasal drug delivery is both challenging and critical. This application notes demonstrates one of many on-going studies that ChemImage conducts using the FALCON II™ Wide-Field Raman Chemical Imaging System to determine chemical identity and particle size distribution (PSD) of micronized drug substances in aqueous suspension nasal spray formulations. These studies are performed in collaboration with the FDA.
ChemImage
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Phenom use for Pharmaceutical Inspection
24 Sep 2008: This application note illustrates how the Phenom can be used as a simple "point and shoot" instrument for the rapid inspection and qualitative characterization of pharmaceutical particles.
FEI Company
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Basic Principles of Particle Size Analysis
 07 Apr 2008: Dispersion processes and the shape of materials makes particle size analysis a complex matter. This technical paper describes how different definitions of the particle size can be obtained depending on the property chosen, as well as how to convert between number, length, and volume/mass means. The merits of different methods for measuring particle sizes using sieves, sedimentation, electrozone sensing, microscopy, and laser diffraction is discussed.
Malvern Instruments
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Measuring Particle Size and Stability of Emulsions
 02 Apr 2008: The Agilent 7020 ZetaProbe allow the direct measurement of particle size and zeta potential in concentrated emulsions without dilution. Diluting samples takes time and can alter the zeta potential. This Application Note illustrates the electroacoustic technique with two case studies: of the destabilisation of an anaesthetic emulsion and of the use of a flow through cell to monitor emulsion production.
Agilent Technologies
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Critical Micellization Temperature (CMT) of Block Copolymers of PEO and PPO
 02 Apr 2008: One of the strengths of light scattering techniques is its capability of detecting aggregation in early stages due to temperature effects, pH, salinity concentration or composition. Any changes in the volume of the scatterer dramatically increase the intensity of light scattered. This Application Note describes the measurement of the micellization of a Pluronic® polymeric surfactant with temperature.
Wyatt Technology Corp.
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Application of QSDFT (Quenched Solid Density Functional Theory) for an Accurate Pore Size Analysis of Disordered Porous Carbons
 01 Apr 2008: The assumptions in NLDFT (non-local density functional theory) methods make analysis of carbons with heterogeneous surfaces and disordered pore surfaces difficult. New QSDFT methods account for surface roughness and heterogeneity explicitly. This Application Note explains the background to the QSDFT methods and demonstrates the significant improvement obtained by comparing experimental and theoretical isotherms of N2 on carbon.
Quantachrome Instruments
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Laser Diffraction for Particle Size Measurement
 01 Apr 2008: When using laser light scattering for particle size analysis, different instrument arrangements and scattering theories can be used to obtain optimum results. By varying the position of the measuring cell between the lens and detector, the resolution of particle size is increased. This Application Note explains the experimental considerations when performing light scattering particle sizing and demonstrates results obtained for polystyrene particles in water using Mie theory analysis.
Fritsch GmbH - Milling and Sizing
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Measuring Ingredient-Specific Particle Size Distribution Using Wide-Field Raman Chemical Imaging
 03 Mar 2008: Intranasal drug delivery is an attractive delivery method for a broad range of pharmaceuticals that treat a variety of diseases. This application note demonstrates how the FALCON II Wide-Field Raman Chemical Imaging system is able to identify chemical makeup and differentiate between multiple components in complex mixtures.
ChemImage
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Continuous Flow for Faster Determinations of Mw and A2
17 Oct 2007: To reduce preparation time and decrease noise levels in light scattering data of imperfect samples, continuous flow moves any large particle through the system more rapidly. This application note describes the use of continuous flow light scattering to measure the Mw and A2 of dextran in water.
Wyatt Technology Corp.
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